Oncology Development Pipeline
RESEARCH & DEVELOPMENT
We continue to build our treatment portfolio with a current focus on oncology within the United States.
Globally, our pipeline includes a robust portfolio of treatments for various therapeutic areas.
At Servier Pharmaceuticals, our core business is focused in oncology where we believe that we have a unique opportunity to redefine how cancer is treated. We are committed to finding solutions that will address today’s challenges. We aim to understand the needs of our patients at all points of their journey, while ensuring those who can benefit from our products have access to them. Advancing innovation for patients is at the heart of everything we do. Servier has significantly accelerated its investment in hard-to-treat cancers with more than 50% of research and development dedicated to deliver significant advances in areas of high unmet need that may truly move the needle for our patients.
Servier’s pipeline includes many oncology assets at varying stages of clinical development.
+35 ONCOLOGY PROJECTS
16
Early research projects
9
Phase 1
2
Phase 2
2
Phase 3
2
Currently Filing
Updated in January 2023
Oncology
SOLID TUMORS
Compound / MOA
Project
Therapeutic area
Phase
FTD/TPI combo bevacizumab
S95005
Solid tumors (new indication)
DPC
1
2
3
Futuximab / modotuximab
combo FTD/TPI
combo FTD/TPI
S95026
Solid tumors (new indication)
DPC
1
2
3
Vorasidenib
S95032
Low grade Glioma with IDH 1/2 mutation
DPC
1
2
3
Ivosidenib
S95031
Solid tumors (new indication)
DPC
1
2
3
Anti-MET
S95027
Non small Cell Lung Cancer
DPC
1
2
3
Vorasidenib + pembrolizumab
S95032
Grade 2-3 glioma with IDH1/2 mutation
DPC
1/2
3
Ivosidenib combo
S95031
Solid tumors (new indication)
DPC
1/2
3
Anti-TIM3 combo
S95018
Solid tumors
DPC
1/2
3
Anti-CD73
S95024
Solid tumors
DPC
1/2
3
Anti-PD-L1/4-1BB
S95012
Solid tumors
DPC
1/2
3
Anti-NKG2A
S95029
Solid tumors
DPC
1/2
3
Inhibiteur de MAT2A
S95035
Solid tumors
DPC
1
2
3
Anti-FLT3
S95040
Solid tumors
DPC
1
2
3
HEMATOLOGICAL MALIGNANCIES
Compound / MOA
Project
Therapeutic area
Phase
Ivosidenib + 7+3 (chimio)
S95031
Hematological malignancies (new indication)
DPC
1
2
3
UCART 19
S68587/S95023
Hematological malignancies
DPC
1
2
3
Calaspargase pegol
S95015
Hematological malignancies (new indication)
DPC
1
2
3
Pegaspargase
S95014
Hematological malignancies (new formulation)
DPC
1
2
3
Ivosidenib
S95031
Hematological malignancies (new indication)
DPC
1/2
3
BCL-2 inhibitor + Mcl1 inhibitor (S64315)
S65487
Acute Myeloid Leukemia
DPC
1/2
3
BCL-2 inhibitor + azacitidine
S65487
1st line Acute Myeloid Leukemia (AML)
DPC
1/2
3
Mcl1 inhibitor + azacitidine
S64315
Relapsed/Refractory Acute Myeloid Leukemia (AML)
DPC
1/2
3
PCD= Preclinical development phase, 1 = Phase 1, 2 = Phase 2, 3 = Phase 3; FTD/TPI: trifluridine/ tipiracil; EGFR: epidermal growth factor receptor; MTAP: Methylthioadenosine Phosphorylase; IDH: Isocitrate dehydrogenase; AYA: Adolescents and Young Adults; MOA: Mode of Action